Protein Details: Two-pore potassium channel 2

Protein ID

ICDB_Pro_1494

Protein Name

Two-pore potassium channel 2

Gene Name

TPK2; KCO2; At5g46370; MPL12.17

Organism

Arabidopsis thaliana (Mouse-ear cress)

Length

443 amino acids

AlphaFoldDB

AF-Q9FL25-F1-model_v4.pdb

Function

Probable voltage-independent potassium-selective tonoplast ion channel.

Sequence

MANDGNGDNNDDPLRQYLMNPRINPPPPSLLTLPENNDVTIPMPITPLELKNRLIFGSFVRSRKESSLPIDALSQNPSTSSSATTSFSDSTDLLLPLTEPNKPVRKSKPTINFHRSKTAPAMAAINNISHPNDPKTDQQSDSKTIVNQAVALLVVYLSLGVLIYWLNRDSYNVKQTHPVVDALYFCIVTMCTIGYGDITPDSVVTKLFSIFFVLVGFGFMDILLSGMVTYVLDLQENYMLETARNESLNLNDRDKVRSYIIDVKKGRMRIRLKVGLALGVVVLCLGFGVLIMHFVEKIGWLDSFYFSVMSVTTVGYGDRAFNTLAGRLLAAMWLLVSTLAVARAILFLAESRVDKRNRERAKKVLGESMSISQFLDADIDCNGCVSKAEFVIYKLKKMDKITEKDINPIGFQFDKLDRTNSGRITLLDLLESSTKDLPTATSI

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

378;380;382;384;389;417;421;423;428

Disease

Location

Expressed in roots; stems; leaves and flowers.

DOI ID

10.1093/dnares/5.2.131; 10.1111/tpj.13415; 10.1111/j.1467-7652.2006.00183.x; 10.1104/pp.126.4.1646; 10.1073/pnas.0401502101; 10.1111/j.1365-313x.2006.02868.x; 10.1111/j.1365-313x.2007.03255.x

RefSeq

NP_199449.1